Floating dosage forms of Verapamil Hydrochloride, used for its anti-anginal and antihypertensive effect, were developed to prolong gastric residence time and increase bioavailability. Present investigation describes the influence of Hydroxypropyl Methylcellulose (HPMC) polymer viscosity and Gas generating agent (GGA) on Verapamil Hydrochloride release from floating matrix tablets. Tablets were prepared using wet granulation technique and were evaluated for in-vitro floating ability and % drug release study. Dissolution profiles were subjected for various kinetic treatments to analyze the release pattern of the drug and result found that drug release by diffusion mechanism. The study shows that tablet composition has great influence on the floating properties and drug release under in-vitro dissolution conditions, the addition of GGA to Verapamil Hydrochloride sustained-release tablets modifies the matrix hydration volume which have important role in drug diffusion. Floating ability was dependent on the amount of effervescent agent and gel-forming polymer of the floating layer. Drug release was prolonged to 12 hours by changing the type and viscosity of the matrix-forming polymer in the drug-loading layer and all formulations showed a diffusion release mechanisms. From the result, it was observed that the kinetics of drug release mainly dependent on viscosity of HPMC and it was modified by incorporation of gas generating agent.
Loading....